Nasal cavity, paranasal sinuses and skull base
Introduction
Hamartomas
Respiratory epithelial adenomatoid hamartoma
Seromucinous hamartoma
Nasal chondromesenchymal hamartoma
Respiratory epithelial lesions
Sinonasal papillomas
Sinonasal papilloma, inverted type
Sinonasal papilloma, oncocytic type
Sinonasal papilloma, exophytic type
Carcinomas
Keratinizing squamous cell carcinoma
Non-keratinizing squamous cell carcinoma
NUT carcinoma
SWI/SNF complex-deficient sinonasal carcinoma (SMARCB1 & SMARCA4)
Sinonasal lymphoepithelial carcinoma
Sinonasal undifferentiated carcinoma
Teratocarcinosarcoma
HPV-associated multiphenotypic sinonasal carcinoma
Adenocarcinoma
Intestinal-type sinonasal adenocarcinoma
Non-intestinal-type sinonasal adenocarcinoma
Mesenchymal tumours of the sinonasal tract
Sinonasal tract angiofibroma
Sinonasal glomangiopericytoma
Biphenotypic sinonasal sarcoma
Chordoma
Other sinonasal tumours
Sinonasal ameloblastoma
Adamantinomatous craniopharyngioma
Meningioma of the sinonasal tract, ear and temporal bone
Olfactory neuroblastoma
Nasopharynx
Introduction
Hamartomas
Hairy polyp
Salivary gland anlage tumour
Carcinomas
Low grade nasopharyngeal papillary adenocarcinoma
Nasopharyngeal carcinoma
Hypopharynx, larynx, trachea and parapharyngeal space
Introduction
Precursor lesions
Squamous papilloma and papillomatosis
Laryngeal and hypopharyngeal epithelial dysplasia
Squamous cell carcinomas
Conventional squamous cell carcinoma
Verrucous carcinoma
Basaloid squamous cell carcinoma
Papillary squamous cell carcinoma
Spindle cell squamous carcinoma
Adenosquamous carcinoma
Lymphoepithelial carcinoma of the larynx
Mesenchymal tumours unique to the hypopharynx, larynx, trachea and parapharyngeal space
Laryngeal cartilaginous tumours
Salivary Gland
Introduction
Non-neoplastic epithelial lesions
Nodular oncocytic hyperplasia
Lymphoepithelial sialadenitis
Benign epithelial tumours
Pleomorphic adenoma
Basal cell adenoma
Warthin tumour
Oncocytoma
Salivary gland myoepithelioma
Canalicular adenoma
Cystadenoma of salivary gland
Ductal papillomas
Sialadenoma papilliferum
Lymphadenoma
Sebaceous adenoma
Intercalated duct adenoma and hyperplasia
Striated duct adenoma
Sclerosing polycystic adenoma
Keratocystoma
Malignant epithelial tumours
Mucoepidermoid carcinoma
Adenoid cystic carcinoma
Acinic cell carcinoma
Secretory carcinoma
Microsecretory adenocarcinoma
Polymorphous adenocarcinoma
Hyalinizing clear cell carcinoma
Basal cell adenocarcinoma
Intraductal carcinoma
Salivary duct carcinoma
Myoepithelial carcinoma
Epithelial-myoepithelial carcinoma
Mucinous adenocarcinoma
Sclerosing microcystic adenocarcinoma
Carcinoma ex pleomorphic adenoma
Carcinosarcoma of the salivary glands
Sebaceous adenocarcinoma
Lymphoepithelial carcinoma
Squamous cell carcinoma
Sialoblastoma
Salivary carcinoma, NOS and emerging entities
Mesenchymal tumours specific to the salivary glands
Sialolipoma
Oral cavity and mobile tongue
Introduction
Non-neoplastic lesions
Necrotising sialometaplasia
Multifocal epithelial hyperplasia
Oral melanoacanthoma
Epithelial tumours
Papillomas
Squamous papillomas
Oral potentially malignant disorders & oral epithelial dysplasia
Oral potentially malignant disorders
Oral epithelial dysplasia
Proliferative verrucous leukoplakia
Submucous fibrosis
HPV-associated dysplasia
Squamous cell carcinomas
Oral squamous cell carcinoma
Verrucous carcinoma
Carcinoma cuniculatum
Tumours of uncertain histogenesis
Congenital granular cell epulis
Granular cell tumour
Ectomesenchymal chondromyxoid tumour
Melanotic neuroectodermal tumour of infancy
Oropharynx (base of tongue, tonsils, adenoids)
Introduction
Benign oropharyngeal lesions
Hamartomatous polyps
Epithelial tumours
Squamous cell carcinoma
Squamous cell carcinoma, HPV-associated
Squamous cell carcinoma, HPV-independent
Odontogenic and maxillofacial bone tumours
Introduction
Cysts of the jaws
Radicular cyst
Inflammatory collateral cysts
Surgical ciliated cyst
Nasopalatine duct cyst
Gingival cysts
Dentigerous cyst
Orthokeratinized odontogenic cyst
Lateral periodontal cyst and botryoid odontogenic cyst
Calcifying odontogenic cyst
Glandular odontogenic cyst
Odontogenic keratocyst
Odontogenic tumours
Benign epithelial odontogenic tumours
Adenomatoid odontogenic tumour
Squamous odontogenic tumour
Calcifying epithelial odontogenic tumour
Ameloblastoma, unicystic
Ameloblastoma, extraosseous/peripheral
Ameloblastoma, conventional
Adenoid ameloblastoma
Metastasizing ameloblastoma
Benign mixed epithelial & mesenchymal odontogenic tumours
Odontoma
Primordial odontogenic tumour
Ameloblastic fibroma
Dentinogenic ghost cell tumour
Benign mesenchymal odontogenic tumours
Odontogenic fibroma
Cementoblastoma
Cemento-ossifying fibroma
Odontogenic myxoma
Malignant odontogenic tumours
Sclerosing odontogenic carcinoma
Ameloblastic carcinoma
Clear cell odontogenic carcinoma
Ghost cell odontogenic carcinoma
Primary intraosseous carcinoma, NOS
Odontogenic carcinosarcoma
Odontogenic sarcomas
Giant cell lesions and bone cysts
Central giant cell granuloma
Peripheral giant cell granuloma
Cherubism
Aneurysmal bone cyst
Simple bone cyst
Bone and cartilage tumours
Fibro-osseous tumours and dysplasias
Cemento-osseous dysplasia
Segmental odontomaxillary dysplasia
Fibrous dysplasia
Juvenile trabecular ossifying fibroma
Psammomatoid ossifying fibroma
Familial gigantiform cementoma
Benign maxillofacial bone and cartilage tumours
Osteoma
Osteochondroma
Osteoblastoma
Chondroblastoma
Chondromyxoid fibroma
Desmoplastic fibroma of bone
Malignant maxillofacial bone and cartilage tumours
Osteosarcoma of the jaw
Chondrosarcoma family
Mesenchymal chondrosarcoma
Rhabdomyosarcoma with TFCP2 rearrangement
Tumours of the ear
Introduction
Tumours of the external auditory canal
Chondrodermatitis nodularis chronica helicis
Cystic chondromalacia
Exostosis (osteoma) of the ear
Ceruminous adenoma
Ceruminous adenocarcinoma
Squamous cell carcinoma of the external auditory canal
Tumours of the middle and inner ear
Otosclerosis
Cholesteatoma
Middle ear papilloma
Vestibular schwannoma
Middle ear neuroendocrine tumour (MeNET)
Endolymphatic sac tumour
Middle ear squamous cell carcinoma
Middle ear adenocarcinoma
Soft tissue tumours
Introduction
Adipocytic tumours
Lipoma family
Liposarcoma family
Fibroblastic and myofibroblastic tumours
Nodular fasciitis
Desmoid fibromatosis
Solitary fibrous tumour
Low grade myofibroblastic sarcoma
Inflammatory myofibroblastic tumour
Vascular tumours
Haemangioma
Epithelioid haemangioma
Lymphangioma
Epithelioid haemangioendothelioma
Kaposi sarcoma
Angiosarcoma
Pericytic (perivascular) tumours
Myofibroma
Smooth muscle tumours
Leiomyoma
EBV-associated smooth muscle tumour
Smooth muscle tumour of uncertain malignant potential
Leiomyosarcoma
Skeletal muscle tumours
Rhabdomyoma
Rhabdomyosarcoma family
Chondro-osseous tumours
Chondroma
Peripheral nerve sheath tumours
Neurofibroma
Schwannoma
Neuromas
Malignant peripheral nerve sheath tumour
Tumours of uncertain differentiation
Phosphaturic mesenchymal tumour
Myxoma
Extraskeletal myxoid chondrosarcoma
Synovial sarcoma
GLI1-altered soft tissue tumour
Undifferentiated sarcoma
Undifferentiated small round cell sarcomas of bone and soft tissue
Ewing sarcoma
Haematolymphoid proliferations and neoplasia
Introduction
Reactive haematolymphoid and related lesions
Reactive lymphoid hyperplasia
EBV+ mucocutaneous ulcer
IgG4-related disease
Myeloid tumours
Extramedullary myeloid sarcoma
B cell lymphomas
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
Mantle cell lymphoma
Follicular lymphoma
Paediatric-type follicular lymphoma
Large B-cell lymphoma with IRF4 rearrangement
Diffuse large B-cell lymphoma
Burkitt lymphoma
Plasmacytoma
Plasmablastic lymphoma
T/NK cell tumours
T-lymphoblastic leukaemia/lymphoma
Primary mucosal CD30-positive T-cell lymphoproliferative disorder
Extranodal NK/T-cell lymphoma
Hodgkin Lymphoma
Hodgkin lymphoma
Histocytic and dendritic cell tumours
Juvenile xanthogranuloma
Erdheim Chester disease
Rosai-Dorfman disease
Langerhans cell histiocytosis
Follicular dendritic cell sarcoma
Melanocytic tumours
Introduction
Mucosal melanoma
Tumours and tumour-like lesions of the neck and lymph nodes
Introduction
Cysts and cyst-like lesions
Ranula
Lymphoepithelial cyst
Branchial cleft cyst
Thyroglossal duct cyst
Dermoid and teratoid cysts
Other tumours
Branchioma
Heterotopia-associated carcinoma
Squamous carcinoma of unknown primary site
Germ cell tumours
Germ cell tumours of the head and neck
Metastasis
Metastases to head and neck region
Neuroendocrine neoplasms and paraganglioma
Introduction
Neuroendocrine neoplasms
Neuroendocrine tumours
Neuroendocrine tumour
Ectopic or invasive PitNET/adenoma
Neuroendocrine carcinoma
Small cell neuroendocrine carcinoma
Large cell neuroendocrine carcinoma
Merkel cell carcinoma
Paraganglion tumours
Head and neck paraganglioma
Genetic tumour syndromes
Introduction
Naevoid basal cell carcinoma (Gorlin) syndrome
Neurofibromatosis (NF1)
Familial Adenomatous Polyposis with Gardner syndrome
Brooke-Spiegler and related syndromes
Cowden syndrome
Familial paraganglioma syndromes
Multiple endocrine neoplasia type 2
Hyperparathyroidism jaw tumour syndrome
Li Fraumeni syndrome
Fanconi anaemia
Dyskeratosis congenita
Ataxia telangiectasia
Bloom syndrome
Von-Hippel Lindau
Tuberous sclerosis syndrome
