Soft Tissue and Bone Tumours

Soft tissue tumours

    Soft tissue tumours: Introduction

    Adipocytic tumours

         Lipoma
         Lipomatosis
         Lipomatosis of nerve
         Lipoblastoma and lipoblastomatosis
         Angiolipoma
         Myolipoma of soft tissue
         Chondroid lipoma
         Spindle cell lipoma and pleomorphic lipoma
         Hibernoma
         Atypical spindle cell / pleomorphic lipomatous tumour
         Atypical lipomatous tumour / well-differentiated liposarcoma
         Dedifferentiated liposarcoma
         Myxoid liposarcoma
         Pleomorphic liposarcoma
         Myxoid pleomorphic liposarcoma

    Fibroblastic and myofibroblastic tumours

         Nodular fasciitis
         Proliferative fasciitis and proliferative myositis
         Myositis ossificans and fibro-osseous pseudotumour of digits
         Ischaemic fasciitis
         Elastofibroma
         Fibrous hamartoma of infancy
         Fibromatosis colli
         Juvenile hyaline fibromatosis
         Inclusion body fibromatosis
         Fibroma of tendon sheath
         Desmoplastic fibroblastoma
         Myofibroblastoma
         Calcifying aponeurotic fibroma
         EWSR1-SMAD3-positive fibroblastic tumour (emerging)
         Angiomyofibroblastoma
         Cellular angiofibroma
         Angiofibroma of soft tissue
         Nuchal-type fibroma
         Acral fibromyxoma
         Gardner fibroma
         Palmar fibromatosis and plantar fibromatosis
         Desmoid fibromatosis
         Lipofibromatosis
         Giant cell fibroblastoma
         Dermatofibrosarcoma protuberans
         Solitary fibrous tumour
         Inflammatory myofibroblastic tumour
         Low-grade myofibroblastic sarcoma
         Superficial CD34-positive fibroblastic tumour
         Myxoinflammatory fibroblastic sarcoma
         Infantile fibrosarcoma
         Adult fibrosarcoma
         Myxofibrosarcoma
         Low-grade fibromyxoid sarcoma
         Sclerosing epithelioid fibrosarcoma

    So-called fibrohistiocytic tumours

         Tenosynovial giant cell tumour
         Deep fibrous histiocytoma
         Plexiform fibrohistiocytic tumour
         Giant cell tumour of soft tissue

    Vascular tumours

         Haemangiomas
              Synovial haemangioma
              Intramuscular angioma
              Arteriovenous malformation/haemangioma
              Venous haemangioma
         Anastomosing haemangioma
         Epithelioid haemangioma
         Lymphangioma and lymphangiomatosis
         Tufted angioma and kaposiform haemangioendothelioma
         Retiform haemangioendothelioma
         Papillary intralymphatic angioendothelioma
         Composite haemangioendothelioma
         Kaposi sarcoma
         Pseudomyogenic haemangioendothelioma
         Epithelioid haemangioendothelioma
         Angiosarcoma

    Pericytic (perivascular) tumours

         Glomus tumour
         Myopericytoma, including myofibroma
         Angioleiomyoma

    Smooth muscle tumours

         Leiomyoma
         EBV-associated smooth muscle tumour
         Inflammatory leiomyosarcoma
         Leiomyosarcoma

    Skeletal muscle tumours

         Rhabdomyoma
         Embryonal rhabdomyosarcoma
         Alveolar rhabdomyosarcoma
         Pleomorphic rhabdomyosarcoma
         Spindle cell / sclerosing rhabdomyosarcoma
         Ectomesenchymoma

    Gastrointestinal stromal tumour

         Gastrointestinal stromal tumour

    Chondro-osseous tumours

         Soft tissue chondroma
         Extraskeletal osteosarcoma

    Peripheral nerve sheath tumours

         Schwannoma
         Neurofibroma
         Perineurioma
         Granular cell tumour
         Dermal nerve sheath myxoma
         Solitary circumscribed neuroma
         Ectopic meningioma and meningothelial hamartoma
         Benign triton tumour / neuromuscular choristoma
         Hybrid nerve sheath tumour
         Malignant peripheral nerve sheath tumour
         Malignant melanotic nerve sheath tumour

    Tumours of uncertain differentiation

         Intramuscular myxoma
         Juxta-articular myxoma
         Deep (aggressive) angiomyxoma
         Atypical fibroxanthoma
         Angiomatoid fibrous histiocytoma
         Ossifying fibromyxoid tumour
         Myoepithelioma, myoepithelial carcinoma, and mixed tumour
         Pleomorphic hyalinizing angiectatic tumour of soft parts
         Haemosiderotic fibrolipomatous tumour
         Phosphaturic mesenchymal tumour
         NTRK-rearranged spindle cell neoplasm (emerging)
         Synovial sarcoma
         Epithelioid sarcoma
         Alveolar soft part sarcoma
         Clear cell sarcoma of soft tissue
         Extraskeletal myxoid chondrosarcoma
         Desmoplastic small round cell tumour
         Extrarenal rhabdoid tumour
         PEComa
         Intimal sarcoma
         Undifferentiated sarcoma

Undifferentiated small round cell sarcomas of bone and soft tissue

         Ewing sarcoma
         Round cell sarcoma with EWSR1-non-ETS fusions
         CIC-rearranged sarcoma
         Sarcoma with BCOR genetic alterations

Bone tumours

         Bone tumours: Introduction

    Chondrogenic tumours

         Subungual exostosis
         Bizarre parosteal osteochondromatous proliferation
         Periosteal chondroma
         Enchondroma
         Osteochondroma
         Chondroblastoma
         Chondromyxoid fibroma
         Osteochondromyxoma
         Synovial chondromatosis
         Central atypical cartilaginous tumour / chondrosarcoma, grade 1
         Secondary peripheral atypical cartilaginous tumour / chondrosarcoma, grade 1
         Central chondrosarcoma, grades 2 and 3
         Secondary peripheral chondrosarcoma, grades 2 and 3
         Periosteal chondrosarcoma
         Clear cell chondrosarcoma
         Mesenchymal chondrosarcoma
         Dedifferentiated chondrosarcoma

    Osteogenic tumours

         Osteoma
         Osteoid osteoma
         Osteoblastoma
         Low-grade central osteosarcoma
         Osteosarcoma
         Parosteal osteosarcoma
         Periosteal osteosarcoma
         High-grade surface osteosarcoma
         Secondary osteosarcoma

    Fibrogenic tumours

         Desmoplastic fibroma of bone
         Fibrosarcoma of bone

    Vascular tumours of bone

         Haemangioma of bone
         Epithelioid haemangioma of bone
         Epithelioid haemangioendothelioma of bone
         Angiosarcoma of bone

    Osteoclastic giant cell-rich tumours

         Aneurysmal bone cyst
         Giant cell tumour of bone
         Non-ossifying fibroma

    Notochordal tumours

         Benign notochordal cell tumour
         Conventional chordoma
         Dedifferentiated chordoma
         Poorly differentiated chordoma

    Other mesenchymal tumours of bone

         Chondromesenchymal hamartoma of chest wall
         Osteofibrous dysplasia
         Adamantinoma of long bones
         Simple bone cyst
         Fibrocartilaginous mesenchymoma
         Fibrous dysplasia
         Lipoma and hibernoma of bone
         Leiomyosarcoma of bone
         Undifferentiated pleomorphic sarcoma
         Bone metastases

    Haematopoietic neoplasms of bone

         Solitary plasmacytoma of bone
         Primary non-Hodgkin lymphoma of bone
         Langerhans cell histiocytosis
         Erdheim-Chester disease
         Rosai-Dorfman disease

Genetic tumour syndromes of soft tissue and bone

         Genetic tumour syndromes of soft tissue and bone: Introduction
         Enchondromatosis
         Li-Fraumeni syndrome
         McCune-Albright syndrome
         Multiple osteochondromas
         Neurofibromatosis type 1
         Rothmund-Thomson syndrome
         Werner syndrome